Rostrum® Oral Suspension

Oral suspension.

Broad-spectrum antibacterial.

Each mL of oral suspension contains:
Enrofloxacin……………………. 25 mg
Excipients c.s.p. ………………… 1 mL

Enrofloxacin is a synthetic antimicrobial agent belonging to the Fluoroquinolone family, which are characterized by being bactericidal antibiotics that have a powerful antibacterial activity against a wide variety of microorganisms, mainly against Gram-negative, Gram-positive bacteria, Mycoplasmas and Chlamydia.

Rostrum® is a broad-spectrum antibacterial, recommended for the treatment of:

• Gastrointestinal tract infections (Escherichia coli, Salmonella spp., Proteus spp.).
  
• Respiratory tract infections (Pasteurella spp., Bordetella spp., Klebsiella spp.).
• Genitourinary infections such as nephritis, pyelonephritis, cystitis (Escherichia coli, Corynebacterium pyogenes, Staphylococcus aureus, Streptococcus spp. and Pseudomonas aeruginosa).
• Skin infections.
• Ear canal infections and otitis (Escherichia coli, Staphylococcus aureus, Streptococcus spp. and Pseudomonas aeruginosa).
• Dermatitis, infected wounds (Escherichia coli, Klebsiella spp., Staphylococcus aureus,
  Streptococcus spp. and Pseudomonas aeruginosa).

Oral route of administration.

• Dosage of the active ingredient:
  – Dogs: 5 – 20 mg/kg body weight once daily for 7-10 days. The dose can be administered as a single dose or divided into two equal doses, given every 12 hours.
  – Cats: 5 mg/kg body weight once a day for 7-10 days. The dose can be administered as a single dose or divided into two equal doses, given every 12 hours. In case of mycoplasma infection, the duration of treatment should be 14 to 21 days.
• Product Dosage:
  

* The dose can be administered as a single dose or divided into two equal doses, administered every 12 hours. In case of mycoplasmosis, the duration of treatment should be 14 to 21 days.

Dogs and cats.

• Enrofloxacin is contraindicated in animals with hypersensitivity to quinolones.
• Do not administer to small to medium breed dogs under 1 year of age, or large breed dogs under 1 1/2 years of age.
• Do not administer to cats under 8 weeks of age.
• The use of Enrofloxacin may cause the formation of crystals in urine, so it is recommended not to administer it in dehydrated animals.
• Do not administer to pregnant or lactating females.

• Arthropathies have been reported in immature animals, especially dogs. The risk of arthropathy increases when the dose is increased, however it has also been reported when recommended doses are used in dogs.
• Other adverse effects that have been described in very rare cases (less than 1 animal in 10,000 animals, including isolated reports) include vomiting, anorexia, increased liver enzymes, ataxia, seizures, depression, lethargy, and nervousness.

• Compounds containing di- or trivalent cations such as Aluminum, Calcium, Magnesium, Iron or Zinc may decrease the absorption of Enrofloxacin. Thus, for example, antacids containing cations (Mg2+, Al3+, Ca2+) can bind Enrofloxacin and prevent its absorption.
• Sucralfate may inhibit the absorption of enrofloxacin. It is recommended to separate both dosages for at least two hours.
• Enrofloxacin given with Theophylline may increase your serum levels. In dogs, theophylline clearance was reduced by 43% when administered in conjunction with enrofloxacin at doses of 5 mg/kg every 24 hours.
• Concomitant administration with other drugs that have hepatic metabolism may affect the pharmacokinetics of one or both drugs.

• Keep out of reach of children and pets.
• Fluoroquinolones, such as Enrofloxacin, should not be used as a first line of treatment, unless no therapeutic alternative is available. When used as a second treatment, it should be on the basis of susceptibility studies.

Wash your hands after administering the product.

Dispose of unused product residues in their original packaging. Do not dispose of the empty container or with product residues in rivers, lakes or natural water streams. Dispose of waste of this product with caution along with household waste.

• Store at room temperature between 15 and 30°C in a dry place.
• Protect yourself from light.
• Do not freeze.
• Once opened, use the product within 3 months. Discard the unused product after that period of time.

For Chile: Sale under prescription Retained Veterinary Doctor.
For Export: Sale under prescription Veterinary Doctor.

VETERINARY USE

Chile: Reg. SAG N° 2038
Costa Rica: Reg. No. MV-6094
Bolivia: Reg. SENASAG PUV-F-N° 006146/14
Peru: Reg. SENASA F.82.02.I.0386
Rep. Dominican:Reg. No. 12567

Laboratorio Drag Pharma Chile Invetec S.A.
Lautaro N° 300. Quilicura. Santiago. Chile.

Chile: Reg. S.A.G. N° 2038
Bolivia: Reg. SENASAG PUV-F-N° 006146/14
Costa Rica: MAG CL4-5-60-6094