Oftavet® Ophthalmic Solution
Topical antibiotic
Oftavet® Ophthalmic Solution is a topical antibiotic indicated to treat superficial and deep ocular infections of the eye and its adnexa, including corneal ulcers infected with drug-sensitive bacteria.
Data Sheet
Ophthalmic solution.
Topical antibiotic.
Each 1 mL of product contains:
Ciprofloxacin Hydrochloride Monohydrate………………. 3.49 mg
(Equivalent to 0.3% Ciprofloxacin base)
Disodium EDTA Anhydrous…………………………………………….. 2.33 mg
Excipients c.s.p…………………………………………………………. 1 mL
Ciprofloxacin is a fluoroquinolone with bactericidal action. Its action is based on the inhibition of bacterial DNA gyrase or topoisomerase IV (a type of topoisomerase II), thereby preventing DNA supercoiling and replication. Respiration and cell division end, and other processes, including membrane integrity, are disrupted. Ciprofloxacin has a broad spectrum of activity, being highly effective against the most commonly encountered eye pathogens, both Gram-positive and Gram-negative, such as: Staphylococcus spp., Streptococcus spp., Pseudomonas aeruginosa, Pasteurella multocida, E. coli, etc.
EDTA inhibits metalloproteinases by chelation of zinc and calcium which the enzyme requires as a co-factor and a stabilizing ion, respectively. By chelating the calcium ion, EDTA interferes with the stability of metalloproteinases and thus decreases stimulation for the migration of polymorphonuclear leukocytes to the corneal ulcer site. EDTA also interferes with the adhesion of metalloproteinases to the polymorphonuclear cell membrane, bringing the cell membrane into an inactivated state. EDTA exhibits a high rate of anti-metalloproteinase activity in vitro (99.4%).
Oftavet® Ophthalmic Solution is a topical antibiotic indicated to treat superficial and deep ocular infections of the eye and its adnexa, including corneal ulcers infected with drug-sensitive bacteria.
Horses, dogs and cats.
Topical administration by instillation into the lower eye sac.
Administer aseptically. Wash your hands before handling and avoid letting the bottle come into contact with the patient’s eyes.
- Horses: 2 drops every 6 hours for 7 days.
- Dogs and cats: 1 drop every 6 hours for 7 days.
Do not administer to horses intended for human consumption.
- For ophthalmic use only.
- Fluoroquinolones, such as Ciprofloxacin, should not be used as a first-line
treatment, unless there is no therapeutic alternative available. When used
As a second treatment, it should be based on susceptibility studies. - Keep out of reach of children.
A hypersensitivity may cause erythema, itching, swelling, tearing. In case of hypersensitivity reaction, discontinue use and consult a veterinarian.
The use of Ciprofloxacin ophthalmic administered in concentrations of 0.3% and 0.75% for one month in Beagle puppies does not produce any adverse effects, both local and systemic
Since there is no history of the use of ciprofloxacin via the eye in pregnant females, it is recommended not to use it in this state, nor during lactation.
- Oftavet® Ophthalmic Solution is contraindicated in patients with hypersensitivity to active ingredients or other quinolones.
- Do not use in pregnant or lactating females.
Synergism with aminoglycosides, 3rd generation cephalosporins, and broad-spectrum penicillins may occur.
To decrease the risk of contact, people who are hypersensitive to quinolones should wear rubber gloves to avoid contact. In case of skin contact, immediately wash the affected area with plenty of water. If irritation persists, consult a doctor. In case of eye contact, wash immediately with plenty of water, if vision is blurred, take immediately to a care center.
Store at a temperature between 2 and 30°C, away from light. Once opened, use within 4 weeks and keep at a temperature between 15 and 30°C, away from light. Discard the unused product after that period of time.
Dispose of unused product residues in their original packaging. Do not dispose of the empty container or the product with traces of product in rivers, lakes or natural water streams. Dispose of waste of this product with caution along with household waste. Contact the manufacturing company or companies specialized in waste disposal, to receive recommendations on the disposal of expired or unused products.
VETERINARY USE
Sale under prescription Withheld Veterinary Doctor.
Chile: Reg. SAG No 2105
Pack with 5 mL
Laboratorio Drag Pharma Chile Invetec S.A.
Lautaro N° 300. Quilicura. Santiago. Chile.
*Important:
You have accessed information referring to pharmaceutical products authorized for sale under a medical prescription. In accordance with Chilean legislation, the promotion and advertising of these products is restricted to professionals who prescribe and dispense them. The information contained on this page is specialized technical and scientific information.
