Cabatina® Injectable

Injectable solution.

Initial emergency treatment for anticoagulant rodenticide poisoning.

Dogs.

Each 1 mL of injectable solution contains:
Phytomenadione………………..……………..10 mg
Excipients c.s.p………………………………….1 mL

Vitamin K is a cofactor in the last stage of hepatic synthesis of coagulation factors II (prothrombin), VII (proconvertin), IX (thromboplastin component of plasma) and X (Stuart factor).
In veterinary medicine, the most frequent cause of cessation of formation of K-dependent coagulation factors is poisoning by anticoagulant rodenticides.
Phytomenadione (Vitamin K1) antagonizes the effects of anticoagulant rodenticides and allows the production process of K-dependent coagulation factors to be reactivated.

Cabatina® Injection is indicated for the initial emergency treatment of acute and super-acute poisonings generated by anticoagulant rodenticides.

• Initial emergency treatment:
  Administer 2.5 to 5 mL of Cabatina® Injectable product per 10 kg of body weight (equivalent to 2.5 – 5 mg/kg of body weight of Phytomenadione, respectively) , in a single dose. According to the evolution of the clinical picture, type of rodenticide responsible for the poisoning and the criteria of the treating Veterinarian, continue the treatment with another veterinary medicine based on Phytomenadione for oral administration.
• Cases that require continuing with injectable treatment:
  In those cases that after the emergency dose, it is not possible to establish oral administration therapy, treatment can be continued with the product Cabatina® Injectable, in a dose of 2 .5 mL of product per 10 kg of body weight (equivalent to 2.5 mg/kg of body weight of Phytomenadione), every 12 hours, with a maximum of 4 administrations in total.
  The duration of the injectable treatment (between 1 to 4 administrations) will depend on the type of rodenticide responsible for the poisoning, the evolution of the clinical picture and the criteria of the treating Veterinarian. Subsequently, the treatment can be continued with another veterinary medicine based on Phytomenadione administered orally.

Subcutánea.

Administer the dose of the product at several injection points to accelerate its absorption and using the smallest gauge needles possible, to minimize the risk of bleeding.

• Therapy with Cabatina® Injectable administered subcutaneously should be continued by the oral administration of Phytomenadione (Vitamin K1).
• In animals with vomiting, anorexia or in acute/super-acute conditions, in which Phytomenadione (Vitamin K1) cannot be administered orally, subcutaneous administration is recommended, however, subcutaneous administration should be replaced by orally, as soon as possible.
• Subcutaneous injections may be poorly absorbed in hypovolemic animals.
• Phytomenadione (Vitamin K1) does not correct hypoprothrombinemia resulting from hepatocellular damage.
• In case of emergency due to lack of coagulation factors, blood transfusions or blood products must be administered, since approximately 6 to 12 hours are needed from the administration of Phytomenadione (Vitamin K1) for new coagulation factors to form .
• Keep out of reach of children and pets.

The following medications may prolong or potentiate the effects of anticoagulants and antagonize some of the therapeutic actions of Phytomenadione (Vitamin K1): Phenylbutazone, Acetylsalicylic acid, Chloramphenicol, Sulfonamides (including Sulfa/Trimethoprim), Diazoxide, Allopurinol, Cimetidine, Metronidazole, anabolic steroids, Erythromycin, Ketoconazole, Propranolol and thyroid drugs, therefore it is not recommended to use concomitantly with other pharmaceutical products.

• Do not administer to animals with known hypersensitivity to Phytomenadione (Vitamin K1).
• Do not administer to patients with severe hepatic insufficiency.
• Do not administer intravenously due to the risk of anaphylactic reactions.
• Do not administer intramuscularly due to the risk of bleeding and hematomas.
• Do not administer the product for more than 4 administrations due to the risk of producing hemolysis.

La Fitomenadiona (Vitamina K1) exógena ingresa en la leche y atraviesa la barrera placentaria. No existen investigaciones formales sobre la seguridad de la Fitomenadiona durante la gestación, por lo tanto, utilícese únicamente de acuerdo a la evaluación beneficio/riesgo efectuada por el Médico Veterinario tratante.

• Altas dosis de Fitomenadiona (Vitamina K1) deben ser administradas con precaución debido a que se han reportado cuadros de Anemia por cuerpos de Heinz en perros que recibieron dosis de 4 mg/Kg por 5 días.
• En algunos perros se han reportado casos de urticaria y formación de abscesos luego de la administración subcutánea de Fitomenadiona (Vitamina K1).

• In the case of ocular exposure, the eyes should be irrigated with copious amounts of water at room temperature for at least 15 minutes. If irritation, pain, inflammation, tearing or photophobia persists, the patient should be evaluated by a doctor.
• In the case of dermal exposure, contaminated clothing should be removed and the exposed area washed thoroughly with soap and water. If there is irritation or pain, the patient should be evaluated by a doctor.
• In the case of accidental injection, medical attention should be sought.

Keep the product, closed or once opened, at a temperature between 2 and 30 ºC, protected from light.
Once opened, use the product within 2 weeks. Discard unused product after that period of time.

Discard unused product remains in its original tightly closed container. Dispose of waste from this product with caution with household waste.

Sale under Veterinary Medical prescription.

VETERINARY USE

Chile: Reg. SAG N° 2329
Bolivia: Reg. SENASAG PUV-No 009995/21

Ampoule bottle with 20 mL.

Laboratorio Drag Pharma Chile Invetec S.A.
Lautaro N° 300. Quilicura. Santiago. Chile.