Dalmarelin®

Injectable solution.

Synthetic analog of GnRH.

Cows and mares.

Each mL of solution for injection contains:
Active principle:
Lecirelin Acetate …………………………………26.5 μg
(equivalent to 25 μg of Lecirelin)
Excipients csp ……………………………………….1 mL

DALMARELIN is an injectable aqueous solution containing lecirelin, a synthetic analogue of the hypothalamic polypeptide hormone GnRH, which induces the release of the gonadotropin hormones LH and FSH from the frontal pituitary.
Lecirelin differs from natural hormones in that it is a nonapeptide and not a decapeptide by substitution of glycine in the tenth position with a highly lipophilic ethyl amine. This change in structure increases the affinity for specific pituitary receptors, resulting in an increase in LH and FSH levels, as well as a prolongation of their effects for a period greater than 240 minutes, unlike the 90 minutes of the natural hormone.
DALMARELIN is indicated in cases of low fertility due to immaturity or delayed maturity of the follicle and ovulation due to insufficient secretion of FSH and LH by the pituitary gland. The inoculation of gonadotropins determines exogenous effects that are not physiologically controllable. On the other hand, the administration of DALMARELIN determines the secretion of pituitary gonadotropins that is controllable by the body through negative feedback mechanisms.

Cows:

• Treatment and prevention of follicular ovarian cysts.
• Induction of ovulation at the time of insemination in cases of short, prolonged or silent heat.

Mares:

• Ovulation induction.
• Improving conception rate.

None.

The recommended route of administration is intramuscular.

Cows:

• Treatment of follicular ovarian cysts
  50 μg of lecirelin (intramuscular route), equivalent to 2 ml of product, per animal once the existence of a cyst has been confirmed. If after 10 days no disappearance or luteinization has occurred, apply a second dose of 100 μg of lecirelin (intramuscularly), equivalent to 4 ml of product.
• Prevention of follicular ovarian cysts
  In cows with a history of previous lactations of follicular cysts, apply 50 μg of lecirelin (intramuscularly), equivalent to 2 ml of product, on day 14 postpartum.
• Induction of ovulation at the time of insemination in cases of short, prolonged or silent cycles
  50 μg of lecirelin (intramuscular route), equivalent to 2 ml of product at the time of insemination.

Mares:

• Induction of ovulation and improvement of conception rate
  4 ml. Administration is carried out when, after gynecological inspection, a follicle of at least 40 mm in diameter is diagnosed.
  The treatment must be repeated if after a period of 24-36 hours there is no ovulation.

• Its use is not recommended during pregnancy.
• In case of contact with the operator’s skin, it is recommended to wash immediately with plenty of soap and water.
• Do not handle pregnant women.
• Keep out of the reach of children.

Meat: Zero (0) days.
Milk: Zero (0) hours.

Store between 2 and 25°C, in a cool, dry place, protected from light.

2 years. Once opened, the product is valid for 28 days, maintained in the indicated conservation conditions.

To be supply only on veterinary prescription.

VETERINARY USE

Reg. SAG. N°: 2077-B

Case with 1 bottle of 20 mL of product

FATRO S.p.A. – Via Emilia, 285 – 40064 Ozzano Emilia (Bologna) Italy.

Laboratorio Drag Pharma Chile Invetec S.A.,
Lautaro 300, Quilicura. Santiago de Chile. Bajo licencia de FATRO S.p.A. – Italia