{"id":9679,"date":"2020-08-06T00:00:00","date_gmt":"2020-08-06T03:00:00","guid":{"rendered":"https:\/\/dragpharma.cl\/producto\/calmedrag\/"},"modified":"2024-10-04T13:01:27","modified_gmt":"2024-10-04T16:01:27","slug":"calmedrag","status":"publish","type":"product","link":"https:\/\/dragpharma.cl\/en\/producto\/calmedrag\/","title":{"rendered":"Calmedrag\u00ae"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"<p>Indicated as a treatment for separation anxiety. Treatment with <strong>Calmedrag\u00ae<\/strong> should be supported with behavioral management therapy&#8230;.<\/p>\n<p><span class=\"button-ver-mas\"><a class=\"understrap-read-more-link\" href=\"https:\/\/dragpharma.cl\/en\/producto\/calmedrag\/\">Read more<\/a><span class=\"arrow\"><i class=\"fa fa-angle-right\" aria-hidden=\"true\"><\/i><\/span><\/span><\/p>\n","protected":false},"featured_media":7725,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[1771],"product_tag":[2685,2686,2687,2688,2689,2690,2691],"especies":[1739],"therapeutic_action":[1955],"class_list":{"0":"post-9679","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-cat-tranquilizers-and-or-anesthetics","7":"product_tag-ansiolitico-en","8":"product_tag-ausentron-en","9":"product_tag-calmadrag-en","10":"product_tag-calmedan-en","11":"product_tag-calmedrag-en","12":"product_tag-clomicalm-en","13":"product_tag-clomipramida-en","14":"especies-dogs","15":"therapeutic_action-tranquilizers-and-or-anesthetics-en","17":"first","18":"instock","19":"product-type-simple"},"acf":{"id_favoritos":"1143","segundo_titulo":"Tranquilizers and\/or Anesthetics","efecto_medico":"Anxiolytic","archivos_n":null,"ficha_tecnica":[{"titulo":"Pharmaceutical form","tipo_de_contenido":"contenido","contenido":"Oral tablet.","tabla":null},{"titulo":"Therapeutic action","tipo_de_contenido":"contenido","contenido":"Anxiolytic.","tabla":null},{"titulo":"Target species","tipo_de_contenido":"contenido","contenido":"Dogs","tabla":null},{"titulo":"Properties","tipo_de_contenido":"contenido","contenido":"Clomipramine Hydrochloride is a tricyclic antidepressant that inhibits the presynaptic reuptake of Serotonin and Norepinephrine and thus produces anxiolytic, anticompulsive, antiaggressive and antidepressant effects. As a result, significant changes can be seen in the behavior of dogs subjected to Clomipramine therapies.","tabla":null},{"titulo":"Composition","tipo_de_contenido":"contenido","contenido":"Each tablet contains:\r\nClomipramine Hydrochloride\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026\u2026..\u2026.... 20 mg\r\n(Equivalent to 17.9 mg of Clomipramine base)\r\nExcipients c.s.p\u2026\u2026\u2026\u2026\u2026.\u2026\u2026\u2026\u2026\u2026.................. 1 comp.","tabla":null},{"titulo":"Indications","tipo_de_contenido":"contenido","contenido":"Indicated as a treatment for separation anxiety.\r\nTreatment with <strong>Calmedrag\u00ae <\/strong>should be supported with behavioral management therapy.","tabla":null},{"titulo":"Route and form of administration","tipo_de_contenido":"contenido","contenido":"<ul>\r\n \t<li>Oral route.<\/li>\r\n \t<li>Place the tablet as far back as possible in the dog's snout, keep the snout closed and encourage swallowing.<\/li>\r\n \t<li>It is recommended at the beginning of therapy to administer the product together with food to reduce the possibility of side effects such as vomiting.<\/li>\r\n<\/ul>","tabla":null},{"titulo":"Dosage of the active ingredient","tipo_de_contenido":"contenido","contenido":"2 mg of Clomipramine Hydrochloride per kilogram of body weight (2 mg\/Kg) every 12 hours for 2-3 months","tabla":null},{"titulo":"Product dosage","tipo_de_contenido":"contenido","contenido":"1 tablet of <strong>Calmedrag\u00ae<\/strong> per 10 kg of body weight (1 tablet\/10 kg) every 12 hours for 2-3 months.\r\nIt is advisable to discontinue therapy gradually.","tabla":null},{"titulo":"Precautions","tipo_de_contenido":"contenido","contenido":"Administer with caution to dogs with a history of seizures, gastrointestinal hypomotility, urinary retention, heart rhythm abnormalities, or increased intraocular pressure.","tabla":null},{"titulo":"Unwanted effects","tipo_de_contenido":"contenido","contenido":"<ul>\r\n \t<li>The most frequently observed adverse symptoms and signs include nausea, vomiting, and transient lethargy or drowsiness.<\/li>\r\n \t<li>Sedation typically occurs at the beginning of therapy and is usually self-limiting as soon as dogs become tolerant to it.<\/li>\r\n \t<li>Vomiting has been reported especially in dogs that have received Clomipramine on an empty stomach, so it is recommended to administer it with food.<\/li>\r\n \t<li>There may be, although unlikely, anorexia, diarrhea, overactivity of liver enzymes, and some anticholinergic effects (e.g., dry mouth).<\/li>\r\n<\/ul>","tabla":null},{"titulo":"Overdose","tipo_de_contenido":"contenido","contenido":"Clomipramine in general is a fairly safe medication and tolerated by dogs. In this species, lethal doses are approximately between 50 and 100 mg\/Kg per day orally, that is, 12.5 to 25 times the recommended therapeutic dose. Notwithstanding the above, overdoses with tricyclic antidepressants are life-threatening (arrhythmias, seizures, cardio-respiratory collapse).\r\nThere is no known antidote for Clomipramine.","tabla":null},{"titulo":"Contraindications","tipo_de_contenido":"contenido","contenido":"<ul>\r\n \t<li>Do not administer to animals with known hypersensitivity to tricyclic agents.<\/li>\r\n \t<li>Do not administer to animals weighing less than 2.5 kg.<\/li>\r\n \t<li>Do not administer to male breeding dogs.<\/li>\r\n \t<li>Do not administer to pregnant or lactating females.<\/li>\r\n \t<li>Do not administer to puppies under 6 months of age.<\/li>\r\n \t<li>Do not administer concomitantly with MAO inhibitors (Selegiline, Amitraz).<\/li>\r\n<\/ul>","tabla":null},{"titulo":"Drug interactions","tipo_de_contenido":"contenido","contenido":"<ul>\r\n \t<li>Due to additive effects, Clomipramine should be administered with caution when used concomitantly with other anticholinergic or CNS depressant agents.<\/li>\r\n \t<li>Tricyclic antidepressants used with antithyroid agents may increase the potential risk of agranulocytosis.<\/li>\r\n \t<li>Cimetidine may inhibit the metabolism of tricyclic antidepressants and increase the risk of toxicity.<\/li>\r\n \t<li>Use in combination with sympathomimetic agents may increase the risk of cardiac effects (arrhythmias, hypertension, hyperpyrexia).<\/li>\r\n \t<li>Do not administer concomitantly with MAO inhibitors (Selegiline, Amitraz).<\/li>\r\n<\/ul>","tabla":null},{"titulo":"Operator Precautions","tipo_de_contenido":"contenido","contenido":"<ul>\r\n \t<li>Wash your hands after handling and\/or administering the product.<\/li>\r\n \t<li>Keep away from the reach of children and pets.<\/li>\r\n \t<li>Accidental ingestion should be considered dangerous.<\/li>\r\n \t<li>Use with caution by people with known sensitivity to Clomipramine<\/li>\r\n<\/ul>","tabla":null},{"titulo":"Special precautions for disposal of unused product or waste material","tipo_de_contenido":"contenido","contenido":"Empty containers can be discarded as household waste, without any special precautions. Do not dispose of containers with product remains on the ground or in water courses. For expired or unused products, contact the manufacturing laboratory.","tabla":null},{"titulo":"Storage conditions","tipo_de_contenido":"contenido","contenido":"Store in a cool, dry place at a temperature between 15 and 30\u00b0C.","tabla":null},{"titulo":"Observations","tipo_de_contenido":"contenido","contenido":"<strong>SALE UNDER RETAINED VETERINARY PRESCRIPTION\r\n<\/strong><strong>URUGUAY: EXCLUSIVE SALE UNDER MSP RECIPE (GREEN RECIPE)\r\n<\/strong><strong>VETERINARY USE\r\n<\/strong><strong>KEEP OUT OF THE REACH OF CHILDREN AND PETS<\/strong>","tabla":null},{"titulo":"Registry","tipo_de_contenido":"contenido","contenido":"<strong>Chile: <\/strong>Reg. SAG N\u00b0 2178\r\n<strong>Uruguay:<\/strong> Reg. MGAP N\u00b0 2017A00466\r\n<strong>Bolivia:<\/strong> Reg. SENASAG PUV- no 009999\/21","tabla":null},{"titulo":"Prepared and distributed by","tipo_de_contenido":"contenido","contenido":"<strong><a title=\"Laboratorio Drag Pharma Chile Invetec S.A\" href=\"https:\/\/dragpharma.cl\/\" target=\"_blank\" rel=\"noopener\">Laboratorio Drag Pharma Chile Invetec S.A<\/a>.\r\n<\/strong>Lautaro N\u00b0 300. Quilicura. Santiago. Chile.","tabla":null},{"titulo":"Sin titulo","tipo_de_contenido":"contenido","contenido":"","tabla":null}],"is_featured_product":"","related_prod":[9309,9284,9289]},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Calmedrag\u00ae - Drag Pharma<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dragpharma.cl\/en\/producto\/calmedrag\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Calmedrag\u00ae - Drag Pharma\" \/>\n<meta property=\"og:description\" content=\"Indicated as a treatment for separation anxiety. Treatment with Calmedrag\u00ae should be supported with behavioral management therapy....Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dragpharma.cl\/en\/producto\/calmedrag\/\" \/>\n<meta property=\"og:site_name\" content=\"Drag Pharma\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/web.facebook.com\/dragpharma\/\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-04T16:01:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dragpharma.cl\/wp-content\/uploads\/2023\/05\/CALMEDRAG.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dragpharma.cl\/en\/producto\/calmedrag\/\",\"url\":\"https:\/\/dragpharma.cl\/en\/producto\/calmedrag\/\",\"name\":\"Calmedrag\u00ae - Drag Pharma\",\"isPartOf\":{\"@id\":\"https:\/\/dragpharma.cl\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/dragpharma.cl\/en\/producto\/calmedrag\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/dragpharma.cl\/en\/producto\/calmedrag\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dragpharma.cl\/wp-content\/uploads\/2023\/05\/CALMEDRAG.jpg\",\"datePublished\":\"2020-08-06T03:00:00+00:00\",\"dateModified\":\"2024-10-04T16:01:27+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/dragpharma.cl\/en\/producto\/calmedrag\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/dragpharma.cl\/en\/producto\/calmedrag\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/dragpharma.cl\/en\/producto\/calmedrag\/#primaryimage\",\"url\":\"https:\/\/dragpharma.cl\/wp-content\/uploads\/2023\/05\/CALMEDRAG.jpg\",\"contentUrl\":\"https:\/\/dragpharma.cl\/wp-content\/uploads\/2023\/05\/CALMEDRAG.jpg\",\"width\":800,\"height\":800},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/dragpharma.cl\/en\/producto\/calmedrag\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/dragpharma.cl\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Especies\",\"item\":\"https:\/\/dragpharma.cl\/especies\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Calmedrag\u00ae\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/dragpharma.cl\/#website\",\"url\":\"https:\/\/dragpharma.cl\/\",\"name\":\"Drag Pharma\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/dragpharma.cl\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/dragpharma.cl\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/dragpharma.cl\/#organization\",\"name\":\"Drag Pharma\",\"url\":\"https:\/\/dragpharma.cl\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/dragpharma.cl\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/dragpharma.cl\/wp-content\/uploads\/2023\/01\/logo-drag.png\",\"contentUrl\":\"https:\/\/dragpharma.cl\/wp-content\/uploads\/2023\/01\/logo-drag.png\",\"width\":1106,\"height\":210,\"caption\":\"Drag Pharma\"},\"image\":{\"@id\":\"https:\/\/dragpharma.cl\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/web.facebook.com\/dragpharma\/\",\"https:\/\/www.instagram.com\/dragpharma\/\",\"https:\/\/cl.linkedin.com\/company\/laboratorio-drag-pharma-chile-invetec-sa\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Calmedrag\u00ae - Drag Pharma","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/dragpharma.cl\/en\/producto\/calmedrag\/","og_locale":"en_US","og_type":"article","og_title":"Calmedrag\u00ae - Drag Pharma","og_description":"Indicated as a treatment for separation anxiety. 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