{"id":9133,"date":"2024-04-15T00:00:00","date_gmt":"2024-04-15T03:00:00","guid":{"rendered":"https:\/\/dragpharma.cl\/producto\/itraskin\/"},"modified":"2024-10-07T10:12:21","modified_gmt":"2024-10-07T13:12:21","slug":"itraskin","status":"publish","type":"product","link":"https:\/\/dragpharma.cl\/en\/producto\/itraskin\/","title":{"rendered":"Itraskin\u00ae"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"<p>Indicated for the treatment of fungal infections caused by microorganisms susceptible to itraconazole, such as cutaneous dermatophytoses caused by <em>Microsporum canis in cats<\/em> , dermatitis caused by <em>Malassezia pachydermatis<\/em> in dogs, and systemic infections of fungal origin, such as histoplasmosis, cryptococcosis, blastomycosis and sporotrichosis&#8230;.<\/p>\n<p><span class=\"button-ver-mas\"><a class=\"understrap-read-more-link\" href=\"https:\/\/dragpharma.cl\/en\/producto\/itraskin\/\">Read more<\/a><span class=\"arrow\"><i class=\"fa fa-angle-right\" aria-hidden=\"true\"><\/i><\/span><\/span><\/p>\n","protected":false},"featured_media":7541,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[2109,1747],"product_tag":[2331,2330,2335,2343,2340,2333,2347,2345,2338,2112],"especies":[1739,1737],"therapeutic_action":[1782],"class_list":{"0":"post-9133","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-antifungals-antifungals","7":"product_cat-cat-dermatological","8":"product_tag-dermatophytes-en","9":"product_tag-fungi-en","10":"product_tag-griseofulvin-en","11":"product_tag-itoconazole-en","12":"product_tag-itodal-en","13":"product_tag-itraconazole-en","14":"product_tag-itraskin-en","15":"product_tag-ketoconazole-en","16":"product_tag-mycosis-en","17":"product_tag-ringworm-en","18":"especies-dogs","19":"especies-cats","20":"therapeutic_action-dermatological","22":"first","23":"instock","24":"product-type-simple"},"acf":{"id_favoritos":"976","segundo_titulo":"Dermatological","efecto_medico":"Treatment of fungal infections","archivos_n":null,"ficha_tecnica":[{"titulo":"Dosage form","tipo_de_contenido":"contenido","contenido":"Oral suspension.","tabla":null},{"titulo":"Therapeutic Action","tipo_de_contenido":"contenido","contenido":"Treatment of fungal infections.","tabla":null},{"titulo":"Composition","tipo_de_contenido":"contenido","contenido":"Each mL of oral suspension contains:<br>\nItraconazole..........................20 mg<br>\nExcipients c.s.p.................1 mL<br>","tabla":null},{"titulo":"Properties","tipo_de_contenido":"contenido","contenido":"Itraconazole is a synthetic antifungal agent, belonging to the family of azole derivatives. It was introduced in the 1990s in order to broaden the antifungal spectrum, increase potency compared to other azoles and reduce adverse effects at the digestive level, especially in prolonged therapies.\nThe antifungal action of itraconazole is generated through a multiple mechanism initiated by the inhibition of two cytochromes P450 involved in the biosynthesis of Ergosterol: CYP51 (sterol-14\u03b1 demethylase) and CYP61 (\u039422-desnaturase). Ergosterol is an essential component of the plasma membrane of fungi.","tabla":null},{"titulo":"Indications for use","tipo_de_contenido":"contenido","contenido":"<strong>Itraskin\u00ae<\/strong>, oral suspension, is indicated for the treatment of fungal infections caused by microorganisms susceptible to Itraconazole, such as cutaneous dermatophytoses caused by <em>Microsporum canis in cats<\/em> , dermatitis caused by <em>Malassezia pachydermatis<\/em> in dogs, and systemic infections of fungal origin, such as histoplasmosis, cryptococcosis, blastomycosis and sporotrichosis.","tabla":null},{"titulo":"Target Species","tipo_de_contenido":"contenido","contenido":"Dogs and cats.","tabla":null},{"titulo":"Route of administration","tipo_de_contenido":"contenido","contenido":"Oral administration.","tabla":null},{"titulo":"Dose","tipo_de_contenido":"contenido","contenido":"Cats:\n<table>\n<thead>\n<tr>\n<th>Pathology<\/th>\n<th>Dose<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Dermatophytosis by\nMicrosporum canis:<\/td>\n<td>1 mL every 2 kg of body weight (equivalent to 10 mg\/kg) every 24 hours,\nfor 4 weeks. It is recommended to continue the therapy until cure\nmycological or non-existence of dermatophyte isolation in three\nconsecutive weekly crops.<\/td>\n<\/tr>\n<tr>\n<td>Fungal diseases\n(histoplasmosis,\ncryptococcosis, blastomycosis,\netc.):<\/td>\n<td>0.5 mL per 2 kg body weight (equivalent to 5 mg\/kg) every 12 hours,\nor 1 mL per 2 kg of body weight (equivalent to 10 mg\/kg) every 24\nhours. Therapy should be continued for 2 to 3 months, or up to\nafter 1 month of resolution of the animal's clinical signs.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\nDogs:\n<table>\n<thead>\n<tr>\n<th>Pathology<\/th>\n<th>Dose<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Dermatitis por Malassezia\nPacydermatis:<\/td>\n<td>2.5 mL per 10 kg of body weight (equivalent to 5 mg\/kg) every 24 kg\nhours, for 3 weeks.<\/td>\n<\/tr>\n<tr>\n<td>Fungal diseases\n(blastomycosis,\nhistoplasmosis\nsporotrichosis, etc.):<\/td>\n<td>2.5 mL per 10 kg of body weight (equivalent to 5 mg\/kg) every 24 kg\nhours, for 2 to 3 months, or up to 1 month after resolution\nof the animal's clinical signs.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\u00a0","tabla":null},{"titulo":"Warnings","tipo_de_contenido":"contenido","contenido":"Keep out of reach of children and pets.","tabla":null},{"titulo":"Precautions","tipo_de_contenido":"contenido","contenido":"<ul>\n \t<li>It is recommended to administer the drug in conjunction with the food, to increase its bioavailability.<\/li>\n \t<li>It is recommended to monitor the appetite of treated individuals.<\/li>\n \t<li>In prolonged treatment or in patients with particular risk conditions,\nrecommends routine monitoring of liver enzymes (monthly ALT).<\/li>\n<\/ul>","tabla":null},{"titulo":"Contraindications","tipo_de_contenido":"contenido","contenido":"<ul>\n \t<li>Do not use in patients with hypersensitivity to Itraconazole or other azole agents.<\/li>\n \t<li>Do not use in patients with hepatic impairment or hypochlorhydria.<\/li>\n \t<li>Do not use in females during the gestation and lactation period.<\/li>\n \t<li>Do not use on dogs and cats under 2 months of age.<\/li>\n<\/ul>","tabla":null},{"titulo":"Adverse effects","tipo_de_contenido":"contenido","contenido":"In dogs, the most common adverse effect is anorexia, especially at higher doses. Some cases may suffer from signs of hepatotoxicity, in which case treatment should be discontinued at least temporarily. Liver damage is determined by increased ALT activity. Anorexia is often a symptomatic marker of toxicity and usually occurs in the second month of treatment. Some dogs treated with doses of 10 mg\/kg may develop vasculitis or ulcerative skin lesions and limb edema that may require dose reduction to 5 mg\/kg. These problems usually resolve after the medication is stopped.\nIn cats, adverse effects are dose-related. Gastrointestinal effects (anorexia, weight loss, vomiting), hepatotoxicity (increased ALT, jaundice) and depression have been described. If adverse effects occur and ALT is increased, the drug should be discontinued. Enzyme hyperactivity in the absence of other signs does not necessarily necessitate dose reduction or discontinuation of medication. Once ALT levels normalize and other adverse effects subside, and if necessary, the drug can be restarted at half the dose initially used with closer clinical monitoring.","tabla":null},{"titulo":"Drug Interactions","tipo_de_contenido":"contenido","contenido":"<ul>\n \t<li>Absorption of Itraconazole is reduced by co-administration with proton pump inhibitor antacids (omeprazole) and H2 blockers (Cimetidine, Ranitidine, etc.) or Didanosine.<\/li>\n \t<li>Itraconazole may increase prothrombin times in patients receiving warfarin or other coumarin anticoagulants. Rifamin may increase the metabolism of itraconazole.<\/li>\n \t<li>Itraconazole may increase serum levels of oral antidiabetic agents (e.g., chlorpropamide, glipizide, etc.), which may result in hypoglycemia.<\/li>\n \t<li>Do not use in conjunction with Cisapride, as it may cause ventricular arrhythmias.<\/li>\n \t<li>Itraconazole interacts with certain antihistamines (Terfenadine, Astemizole), benzodiazepines, calcium channel blockers, anticonvulsants, some antimicrobials, and cyclosporine.<\/li>\n \t<li>It is not recommended for use concomitantly with anticholinergics.<\/li>\n<\/ul>","tabla":null},{"titulo":"Precautions for the person administering the product","tipo_de_contenido":"contenido","contenido":"<ul>\n \t<li>Wash your hands after administering the product.<\/li>\n \t<li>In case of contact with the eyes, it is recommended to wash with plenty of water for 15 minutes.<\/li>\n \t<li>In case of accidental ingestion, do not induce vomiting. Get medical attention in case\nnecessary.<\/li>\n<\/ul>","tabla":null},{"titulo":"Storage conditions","tipo_de_contenido":"contenido","contenido":"Store at room temperature below 30\u00b0C. Do not freeze. Once opened, use within 8 weeks. Discard the unused product after that period of time.","tabla":null},{"titulo":"Condition of Sale","tipo_de_contenido":"contenido","contenido":"Sale by prescription to the Veterinary Doctor.","tabla":null},{"titulo":"Records","tipo_de_contenido":"contenido","contenido":"<strong>Chile:<\/strong> Reg. SAG N\u00b0 2053\n<strong>Costa Rica:<\/strong> Reg. No. MV-5639\n<strong>Rep. Dominican:<\/strong>  Reg. N\u00b0 9305\n<strong>Bolivia:<\/strong> Reg. SENASAG PUV-F N\u00b0007252\/16\n<strong>Peru:<\/strong> Reg. SENASA F.33.36.I.0043","tabla":null},{"titulo":"Remarks","tipo_de_contenido":"contenido","contenido":"<strong>VETERINARY USE<\/strong>\n<strong>INCLUDES DISPENSER <\/strong>\n<strong><span style=\"font-size: 12pt;\">SHAKE BEFORE USE<\/span><\/strong>","tabla":null},{"titulo":"Presentation","tipo_de_contenido":"contenido","contenido":"Bottle with 120 mL","tabla":null},{"titulo":"Produced and distributed by","tipo_de_contenido":"contenido","contenido":"<strong><a title=\"Laboratorio Drag Pharma Chile Invetec S.A\" href=\"https:\/\/dragpharma.cl\/\" target=\"_blank\" rel=\"noopener\">Laboratorio Drag Pharma Chile Invetec S.A<\/a>.\n<\/strong>Lautaro N\u00b0 300. Quilicura. Santiago. Chile.","tabla":null}],"is_featured_product":"","related_prod":[9218,9324,9359]},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Itraskin\u00ae - Drag Pharma<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dragpharma.cl\/en\/producto\/itraskin\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Itraskin\u00ae - Drag Pharma\" \/>\n<meta property=\"og:description\" content=\"Indicated for the treatment of fungal infections caused by microorganisms susceptible to itraconazole, such as cutaneous dermatophytoses caused by Microsporum canis in cats , dermatitis caused by Malassezia pachydermatis in dogs, and systemic infections of fungal origin, such as histoplasmosis, cryptococcosis, blastomycosis and sporotrichosis....Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dragpharma.cl\/en\/producto\/itraskin\/\" \/>\n<meta property=\"og:site_name\" content=\"Drag Pharma\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/web.facebook.com\/dragpharma\/\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-07T13:12:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dragpharma.cl\/wp-content\/uploads\/2023\/05\/ITRASKIN.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dragpharma.cl\/en\/producto\/itraskin\/\",\"url\":\"https:\/\/dragpharma.cl\/en\/producto\/itraskin\/\",\"name\":\"Itraskin\u00ae - 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